Oral complications of hematopoietic stem cell transplantatio
- Conditions
- hematopoietic stem cell transplantation, mucositis, graft versus host disease, caries, periodontitisstamceltransplantatie, mucositis, graft versus host ziekte, mondgezondheid
- Registration Number
- NL-OMON23941
- Lead Sponsor
- Academic Center for Dentistry Amsterdam (ACTA)Academic Medical Center Amsterdam (AMC)Radboud Universitair Medisch Centrum, NijmegenCarolina's Medical Center, Charlotte,NC, USASahlgrenska University Hospital Gothenburg, Sweden
- Brief Summary
A number of publications in peer reviewed scientific journals is planned to report the findings of this study
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 102
Inclusion Criteria
Adult hematopoietic stem cell recipients
Exclusion Criteria
Patients unable to give their informed consent
Patients younger than 18 years
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence, severity and temporal relationship of oral complications and their relationship with the type of conditioning regimen by using questionnaaires and physical examination<br /><br>Composition of the oral microbiome, salivary output and proteome before, during and after transplant and assessment of any associations between these components of the oral ecosystem and the development of oral complications
- Secondary Outcome Measures
Name Time Method Identification of other factors than the conditioning regimen to predict oral complications<br /><br>Genetic polymorphisms involved in mucositis<br /><br>Impact of oral complications on clinical and economic outcomes<br /><br>Impact of oral complications on quality of life<br /><br>Composition of the microbiome and any associations with incidence, severity and duration of oral mucositis and graft versus host disease<br /><br>The composition of the salivary proteome and incidence and severity of oral mucositis and graft versus host disease <br>pre-existent periodontal disease and incidence, severity and duration of oral mucositis and graft versus host disease<br>