Access the Influence of Oral Microbiota in the Onset and Evolution of Stroke, With Focus on Cerebral Microbleeds
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 170
- 试验地点
- 2
- 主要终点
- Correlation Between Oral Microbiota and Cerebral Microbleeds in Stroke
研究概览
简要总结
Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases. Streptococcus Mutans (SM) is considered the primary pathogen responsible for dental caries. Furthermore, in cases of oral inflammatory diseases, SM has been found to invade the bloodstream and disseminate, leading to systemic diseases. Against this backdrop, this study aims to investigate disparities in oral flora between stroke patients and healthy individuals by collecting saliva samples from both groups.
详细描述
Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases. Streptococcus Mutans (SM) is considered the primary pathogen responsible for dental caries. Furthermore, in cases of oral inflammatory diseases, SM has been found to invade the bloodstream and disseminate, leading to systemic diseases. Against this backdrop, this study aims to investigate disparities in oral flora between stroke patients and healthy individuals by collecting saliva samples from both groups. The objective of this study is to offer novel insights into the association between oral health and cerebrovascular disease occurrence while establishing a foundation for future research.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Microbleeding/damage or rupture of small blood vessels in the brain has been diagnosed within the past 365 days
- •Have done nuclear magnetic examination and can provide nuclear magnetic results
排除标准
- •Have received antibiotic quality within the last three months
结局指标
主要结局
Correlation Between Oral Microbiota and Cerebral Microbleeds in Stroke
时间窗: 2025.06
Number and volume of microbleeds (measured in mm³)
Estimate the Relationship Between Oral Microbiota and Stroke
时间窗: 2025.06
Measure the diversity and abundance of oral bacteria in stroke patients,units:Number of bacterial species, bacterial counts (CFU/ml)
次要结局
未报告次要终点
研究者
Xiaojing Huang
Archiater
Fujian Medical University