Reduction of antibiotic use in the ICU: Procalcitonin guided versus conventional antibiotic therapy in patients with sepsis in the IC

Withdrawn

Conditions: Sepsis
Septicemia
10004018

Registration Number: NL-OMON33222

Lead Sponsor: Alysis Zorggroep

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

1. Patients admitted to the ICU
2. Age >18 years
3. Antibiotic therapy for sepsis with a suspected or proven focus of infection

Exclusion Criteria

1. Age <18 years
2. Pregnancy
3. Infection or presumed infection requiring prolonged antibiotic therapy (osteomyelitis, meningitis, endocarditis, septic arthritis, mediastinitis, tuberculosis, Pneumocystis jiroveci pneumonia, Toxoplasmosis, Legionellosis, Listeriosis)
4. Indication for prolonged systemic prophylactic antibiotic therapy
5. Severe viral or parasitic infections (hemorrhagic fever, malaria)
6. Antibiotic therapy started 48 hours before enrollment
7. Severe immunocompromised patients (AIDS with a CD4 count<200cells/mm3, severe neutropenia(<500 neutrophils/mm3), patients undergoing immunosuppressive therapy after solid organ transplantation)
8. Patients foregoing lifesustaining treatment.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>· Duration of antibiotic therapy<br /><br>· Antibiotic free days</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>· 28 day mortality<br /><br>· In hospital mortality<br /><br>· ICU LOS<br /><br>· Hospital LOS<br /><br>· Clinical Cure<br /><br>· Reoccurrence of initial infection<br /><br>· Nosocomial superinfection</p><br>