Antibiotic Concentration in Critically ill intensive care unit (ICU) patients in Swede

Not Applicable

Completed

• Conditions: Sepsis; Septic shock; Critical illness; Infection - Other infectious diseases

• Registration Number: ACTRN12616000167460
• Lead Sponsor: ppsala university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Intensive care patient with any severe suspected or verified infection requiring initiation of new antibiotic treatment.

Exclusion Criteria

Intermittent hemodialysis
Known pregnancy
Limitations of care

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess if antibiotic concentrations in plasma are lower than those recommended in current international guidelines.[Days 1-3 of antibiotic therapy.]

Secondary Outcome Measures

Name	Time	Method
To assess if antibiotic concentrations in plasma are higher than those recommended in current international guidelines.[Days 1-3 of antibiotic therapy.];To find mechanistic explanations to variations in plasma antibiotic concentration in this group such as variations in renal function (eGFR), liver function (INR), plasma protein levels (plasma albumin), continuous renal replacement therapy (dose) etc.[Days 1-3 antibiotic therapy.];To relate plasma antibiotic concentration to the MIC values of the isolated bacteria from each patient with positive cultures. [Days 1-3 of antibiotic therapy.]