Determination of antibiotic concentrations in interstitial space fluid of muscle and subcutis in septic patients including a pilot phase
- Conditions
- A41.9Sepsis, unspecified
- Registration Number
- DRKS00005046
- Lead Sponsor
- Knappschaftskrankenhaus BochumKlinik für Anästhesiologie, Intensivmedizin und Schmerztherapie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Severe sepsis or septic shock as diagnosed according to the criteria of ACCP/SCCM and the MAXSEP Study within 24 hours:
Exclusion Criteria
Age < 18 years
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Area under the concentration time curve (AUC), maximum concentration (Cmax), half-life (t1/2) in the microdialysate and plasma after single dose and at steady state.<br>
- Secondary Outcome Measures
Name Time Method Assoziation of 30 days survival in patients withe sepsis dependent on tussues concentrations of antibiotics. Plasma will be revieled with microdialysis and analysed with HPLC.