Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 185
- 试验地点
- 1
- 主要终点
- Spherical Eccentricity (SphEcc)
研究概览
简要总结
Primary objective of this study was evaluate the diagnostic capacity of fourier analysis of keratometric data in differentiating moderate KC and FFK from healthy corneas.
Study participants were recruited from the Cornea Outpatient service in a consecutive if eligible basis. Two study groups were formed: a)KC group included patients those were diagnosed and classified for moderate keratoconus according to the Amsler-Krumeich classification system, b) FFK group (FFKG) that included patients diagnosed with FFK, and c) Control group (CG) was formed by refractive surgery candidates. Pentacam (Pentacam HR, Oculus Optikgerate GmbH, Heidelberg, Germany)measurements were performed by the same experienced operator in a consistent way.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 8 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of keratoconus KC in the fellow eye according to the Amsler-Krumleich criteria (FFKG)
- •KISA index between 60 and 100% in the FFK eye (FFKG)
- •lack of any KC-related findings / signs in the slit-lamp biomicroscopy (FFKG)
- •uneventful ophthalmologic history (CG)
- •no indications of corneal pathology in slit-lamp biomicroscopy and Placido *disk-based videokeratography (CG)
- •KISA index value less than 60% (CG)
- •diagnosed and classified for moderate keratoconus according to the Amsler-Krumeich classification system (KCG)
排除标准
- •for all study groups:
- •previous incisional eye surgery
- •corneal scars and opacities
- •history of herpetic keratitis, severe eye dryness
- •pregnancy or nursing
- •current corneal infection
- •suspicion for glaucoma
- •IOP lowering treatment
- •underlying autoimmune disease
结局指标
主要结局
Spherical Eccentricity (SphEcc)
时间窗: One Day
Spherical Eccentricity is the asphericity that is calculated
Spherical Component (SphRmin)
时间窗: One Day
Spherical Component (SphRmin) displays the arithmetic mean of all radii of curvature for each ring
Total Astigmatism (Tast) which is the sum of Mean Astigmatism and Irregularities.
时间窗: One Day
Total Astigmatism (Tast) is the sum of Mean Astigmatism and Irregularities.
Regular Astigmatism at the Center(AstC)
时间窗: One Day
the regular astigmatic component is calculated in the center and it is derived from the second order component of Fourier Analysis
Mean Astigmatism (MAst)
时间窗: One Day
Mean Astigmatism is the average of astigmatism at the center and the periphery (MAst)
Irregularitiy (Irr)
时间窗: one Day
Maximum Decentration (MaxDec)
时间窗: One Day
decentration or asymmetry of the astigmatic component which is derived from first order component of fourier analysis
Regular Astigmatism at the Periphery (AstP)
时间窗: One day
the regular astigmatic component is calculated in the periphery and it is derived from the second order component of Fourier Analysis
Astigmatism at the Center plus the Irregularities (AstCir)
时间窗: One day
the irregularities of the cornea which can not be corrected by sphere, cylinder or prism and it is derived from higher order components of Fourier Analysis of Keratometric Data
次要结局
未报告次要终点
研究者
Georgios Labiris
Ass. Professor in Ophthalmology
Democritus University of Thrace