ISRCTN03784241
Completed
N/A
Genetically determined brain abnormalities in Down's syndrome - towards a treatment: a randomised, single-blind, placebo-controlled trial of lithium carbonate in Down's syndrome
King's College London (UK)0 sites19 target enrollmentAugust 19, 2009
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Down's syndrome
- Sponsor
- King's College London (UK)
- Enrollment
- 19
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Individuals with Down's syndrome
- •2\. Over the age of 18 years, either sex
- •3\. Able to provide informed consent for themselves or have a representative to provide proxy consent on their behalf if they lack capacity
- •4\. Able to communicate with the investigator and to comply with requirements of the study
- •5\. Has carer support
Exclusion Criteria
- •1\. Individuals with contraindications to lithium treatment
- •2\. Individuals with contraindications to undergoing a magnetic resonance scan
- •3\. Non\-compliance with taking of the tablets between baseline and the final assessment
- •4\. Treatment with lithium within the last 6 months
- •5\. Evidence of dementia
- •6\. Evidence of renal, thyroid or cardiac disease that would contraindicate taking lithium
- •7\. Pregnancy
Outcomes
Primary Outcomes
Not specified
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