Impact of black tea on forearm endothelial functionDe invloed van zwarte thee op de vaatfunctie

Completed

• Conditions: Vascular function; endothelial function; black tea; healthy volunteers; endotheel; gezonde vrijwilligers; hypertensie; blood flow; blood pressure; hypertensionvaatfunctie

• Registration Number: NL-OMON25147
• Lead Sponsor: Department of Physiology, section of Integrative Physiology, Radboudumc Nijmegen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Healthy subjects:
- Males and post-menopausal (> 1 years) females
- Aged >45 and < 75 years
- Body mass index (BMI) between 18.0 and „T35.0 kg

Exclusion Criteria

- Regular performance of strenuous exercise/sport of > 2 hours per week
- Current smoker or has stopped smoking less than 6 months before start of study
- Self reported alcohol intake of >21 units/week)
- Established cardiovascular disease
- Diabetes mellitus
- Blood pressure > 160/100 mmHg
- Subjects taking any medication that might affect endothelial function (e.g. but not limited to beta-blockers, ACE-inhibitors, statins, anti-coagulants, anti-depressants, hormone replacement therapy) will be excluded from the study. Subjects who are on stable medication for which there is no indication of an effect on endothelial function, will be allowed to participate.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean forearm blood flow response (volume change measured by venous occlusion plethysmography) to intra-arterially administered acetylcholine (i.e. endothelium-independent vasodilation)

Secondary Outcome Measures

Name	Time	Method
Mean forearm blood flow response (volume change measured by venous occlusion plethysmography) to intra-arterially administered sodium nitroprusside (i.e. endothelium-dependent vasodilation);<br>Mean forearm blood flow response (volume change measured by venous occlusion plethysmography) to intra-arterially administered sodium L-NMMA(i.e. nitric oxide-blocker; endothelium-dependent vasoconstriction)