Multimodal Therapy Impact on Pancreatic Cancer Survival
- Conditions
- Pancreatic CancerNeoadjuvant ChemotherapyPancreatectomy
- Registration Number
- NCT06938906
- Lead Sponsor
- National Cheng Kung University
- Brief Summary
The goal of this retrospective cohort study is to analyze change of treatment strategies affect the survival outcomes in patients of pancreatic cancer who received curative-intent treatment. The main question it aims to answer is:
Hypothesis: Change of treatment strategies involving increased utility of neoadjuvant chemotherapy and aggressive surgical approaches of extended pancreatectomy improved the overall and progression free survival in the patients with pancreatic cancer.
Participants received curative treatment for pancreatic cancer.
- Detailed Description
This study is to analyze the change of treatment strategies and shift of the paradigm over time in a single center. Researchers plan to see the impact of the evolvement to the survival outcomes in pancreatic cancer.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 405
- Pancreatic adenocarcinoma
- Received curative surgery
- Other subtypes of pancreatic cancer including acinar cell carcinoma, mucinous carcinoma, undifferentiated carcinoma and intraductal papillary mucinous neoplasm with associated adenocarcinoma
- Cases with palliative or R2 resection were also excluded from the analysis.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Overall survival and Progression-free survival From enrollment to two years after the end of treatment Overall survival was calculated from the first treatment day of the disease to the day of mortality. Progression-free survival was calculated from the first treatment day of the disease to the day of proression or recurrece of pancreatic cancer.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan