The effect of therapeutic treatments in the transplant model of psoriasis; in which a psoriatic lesion is induced in non-lesional skin transplanted onto immune-deficient (BNX) mice by injecting super-antigen activated peripheral blood cells intra-dermally into the transplant.
Completed
- Conditions
- psoriasis1000381610014982
- Registration Number
- NL-OMON42470
- Lead Sponsor
- Galderma
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 19
Inclusion Criteria
Patients with psoriasis vulgaris, mild to moderate.
Exclusion Criteria
Volunteers should not:
- use light therapy or systemic drugs such as methotrexate or cyclosporine A.
- use local topical corticosteroids.
- develop psoriasis at wound sites (Köbner phenomenon).
- have other skin diseases.
- be pregnant
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Transplant epidermal thickness.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Number of dividing epidermal keratinocytes.</p><br>