Evaluation of intrarenal oxygenation in patients after receiving a kidney from non-heart-beating and living donors by BOLD MRI on a 3.0 T scanner 1 day after surgery.
Withdrawn
- Conditions
- Transplantatieischemia/reperfusion injurykidney transplantation1002914910038365
- Registration Number
- NL-OMON33999
- Lead Sponsor
- Academisch Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 36
Inclusion Criteria
Patients receiving a kidney from a living donor
Patients reveiving a kidney from a NHB donor
Living donors
Donor age > 18 years
Able to give informed consent
Written informed consent
Exclusion Criteria
Age < 18 years
Donor > 60 years
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Hypoxia<br /><br>1. Medullary and cortical oxygenation (R2*)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Hypoxia<br /><br>1. Medullary and cortical O2 consumption (after furosemide administration)<br /><br>2. Medullary and cortical perfusion (after Gadovist administration)<br /><br>3. Urine HIF-1a and carbonic anhydrase IX concentration<br /><br><br /><br>Kidney function<br /><br>1. Dialysis dependency after transplantation<br /><br>2. Area under the curve for serum creatinine concentration over time (14 days)<br /><br>3. Fractional excretion of sodium (14 days)<br /><br><br /><br>Renal cellular injury<br /><br>1. Examining biopsies according to protocol</p><br>