The role of hypovolaemia In the acidosis of severe malaria in childre

Phase 2

Completed

• Conditions: Severe malaria; Infections and Infestations; Malaria

• Registration Number: ISRCTN58063971
• Lead Sponsor: Imperial College London (UK)

Brief Summary

2003 results in https://www.ncbi.nlm.nih.gov/pubmed/14525636 (added 14/02/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2002-10-01
• Study Start: 2005-07-22
• Last Update Posted: 3 March 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 53

Inclusion Criteria

1. A clinical feature of severe malaria (prostration, coma or deep breathing) plus P. falciparum
2. A base deficit of more than eight
3. Parental consent

Exclusion Criteria

1. Clinical features of oedematous malnutrition
2. Features suggestive of pulmonary oedema (oxygen saturations <90% and bilateral creptitations)
3. Raised intracranial pressure (unequal pupillary reaction to light and/or raised blood pressure concurrent with bradycardia)
3. Refusal of consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage reduction in acidosis by eight hours.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Death<br> 2. Severe adverse events<br> 3. Neurological sequalae<br>