Role of hypovolaemia in the acidosis of severe malaria

Completed

• Conditions: Severe falciparum malaria; Infections and Infestations; Malaria

• Registration Number: ISRCTN35536139
• Lead Sponsor: Imperial College London (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10-14
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

1. Kenyan children aged more than three months, either sex
2. Clinical features of severe falciparum malaria (impaired consciousness and or deep breathing)
3. Metabolic acidosis (base deficit more than or equal to eight)

Exclusion Criteria

1. Children of families who decline consent
2. Children with:
2.1. Severe anaemia (haemoglobin less than 5 g/dl)
2.2. Cerebrospinal fluid (CSF) changes consistent with meningitis
2.3. Clinical features of pulmonary oedema (defined as clinical evidence presence of fine crepitations in both lungs plus oxygen saturations less than 95%)
2.4. Evidence of raised intracranial pressure (brain stem features of coning, systolic blood pressure more than 90% centile for age plus falling heart rate and/or papilloedema)
2.5. Any conditions that may contraindicate the use of volume replacement, e.g. established renal failure or known congenital heart disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified