Modulation of synaptic plasticity by rapid acting antidepressive interventions

Recruiting

• Conditions: F32; Depressive episode

• Registration Number: DRKS00025471
• Lead Sponsor: niversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 324

Inclusion Criteria

Major depression. MADRS > 20.
20-50 years of age.
Naturalistic treatment of one of the interventions desired to investigate.

Exclusion Criteria

comorbid psychiatric disorder
addiction
treatment with other stimulation treatment methods

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes of the amplitudes of early visually evoked potentials after optical stimulation or motor evoked potentials after PAS before and after an rapid antidepressive intervention.

Secondary Outcome Measures

Name	Time	Method
Changes of brain derived neurotrophic factor serum concentration before and after the intervention.<br>Changes of DNA methylisation of relevant promotor regions. <br>Changes of Beck Depression Inventtory (BDI).