Pharmacological modulation of heterosynaptic LOng-TErm POtentiation in humans by ONdansetron and DExtromethorpha

Completed

Conditions: Hyperalgesic pain states in chronic pain patients
Signs and Symptoms
Chronic pain

Registration Number: ISRCTN38944269

Lead Sponsor: Individual Sponsor (Germany)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 18

Inclusion Criteria

1. Healthy volunteers of full age
2. Subject familiarised with the experimental procedure prior to experimentation and had given written informed consent
3. At least a 50% increase of pain to pinprick stimuli and a 25% increase of pain to electrical stimuli following high-frequency electrical stimulation in a screening visit

Exclusion Criteria

1. Skin lesions at the test and/or control site
2. Use of any medication within one day prior to study onset except contraceptives
3. Known hypersensitivity to histamine or to dextromethorphan and ondansetron and their derivates
4. Any history of allergy or drug hypersensitivity
5. Chronic use of analgesics or Central Nervous System (CNS) active drugs
6. Pregnancy or nursing
7. Any acute or chronic disease

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Spread of the area of dynamic allodynia and static hyperalgesia<br>2. Combined analgesic and anti-hyperalgesic effect to mechancial and electrical stimuli on the site of conditioning stimulation

Secondary Outcome Measures

Name	Time	Method
1. Anti-hyperalgesic effect to electrical and mechanical test stimuli <br>2. Analgesic effect to electrical and mechanical test stimuli <br>3. Anti-wind up