Effect of brain and spinal cord stimulation on limb recovery in complete spinal cord injury patients
Not Applicable
- Conditions
- Health Condition 1: S341- Other and unspecified injury of lumbar and sacral spinal cord
- Registration Number
- CTRI/2022/11/047038
- Lead Sponsor
- Department of Biotechnology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Complete spinal cord injury patient with ASIA impairment score A,complete motor and sensory loss below the level of injury
Exclusion Criteria
1.Osteoporotic Fracture
2.History of neurological or orthopaedic disease related to spinal cord
3.Head injury
4.Ferromagnetic metallic implants close to the target stimulation area
5.Pacemaker
6.Cognitive impairment
7.Pregnancy
8.History/family history of seizures
9.Acute eczema/ bed shore under the target stimulation area
An informed consent form will be filled by patients if they fit into the inclusion and exclusion criteria.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method This is the first research based trial using nanotechnology with iTBS for inducing locomotor recovery and also assessing changes in cortical excitability and connectivity in Complete Spinal Cord Injury patients. The proposed intervention of iTBS along with implantation of hydrogel containing neurotrophic factors and IONPs, will augment the restoration of lost functions in complete SCI patients. We expect improvement in the functions below the level of lesion; autonomic functions like urinary and bowel control, locomotion, relief from pain, and psychological well-being.Timepoint: All assessments will be done before and after the intervention. follow-up assessments will be done at 1 month, 2 months and 3 months after the intervention.
- Secondary Outcome Measures
Name Time Method This will improve the quality of life of patients and ease the burden on public health. We presume that this non-invasive, activity-dependent strategy would be able to reduce the etiology of the disease.Timepoint: All assessments will be done before and after the intervention. follow-up assessments will be done at 1 month, 2 months, and 3 months after the intervention.