Modulation of cortical activity with noninvasive neurostimulation in children and adolescents with autism spectrum disorder – A randomized, double-blind and sham-controlled study

Not Applicable

• Conditions: F84.5; F84.1; F84.0; Asperger syndrome; Atypical autism; Childhood autism

• Registration Number: DRKS00017505
• Lead Sponsor: Medizinische Universität Wien, Universitätsklinik für Kinder- und Jugendpsychiatrie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-07-02
• Study Completion: 2021-09-23
• Results First Posted: 2023-08-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

a) participants with ASD; diagnosed using Autism Diagnostic Interview-Revised (ADI-R; Bölte, Rühl, Schmötzer, & Poustka, 2006) and/or Autism Diagnostic Observation Schedule (ADOS; Rühl, Bölte, Feineis-Matthews, & Poustka, 2004);
b) aged between 12 and 18 years;
d) right-handed;
d) IQ > 70;
e) informed consent

Exclusion Criteria

-) all metallic devices (such as cardiac pacemakers, defibrillator, cochlear implant, intracranial/cranial stimulators and other metals)
-) epilepsy or related seizure disorders
-) any implant or stainless steel graft or any other contraindications for MRI
-) other severe neurologic or psychiatric disorders or medical conditions (in particular skull defect, craniotomy)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
As the primary endpoint, autistic symptomatology indicated by the raw score of Social Responsiveness Scale (SRS) (given before and after the intervention) is defined.

Secondary Outcome Measures

Name	Time	Method
As secondary endpoints, psychological and neurophysiological parameters regarding autistic and comorbid symptoms, emotional competencies and behavioral measures (given before and after the intervention) are defined.