The effect of non invasive brain stimulation on lower limb motor control

Completed

Conditions: cerebrovascular accident
Stroke
10007963

Registration Number: NL-OMON38314

Lead Sponsor: niversiteit Twente

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

For healthy subjects
- age>18 years;For stroke survivors
- diagnosed with a hemiparesis as the result of a first ever, ischemic stroke
- chronic stage: time since stroke > 6 months
- independent walkers with clear walking impairment

Exclusion Criteria

- contraincidation to TMS or tDCS
- other neuromuscular disorder or orhopedic problems
- have a history of cardiac conditions that interfere with physical load

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the relative change in single pulse Motor Evoked<br /><br>Potential (MEP) of the Tibialis Anterior and Vastus Lateralis at the post<br /><br>measurements compared to the baseline measurement. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters are change in intermuscular coherence between the Vastus<br /><br>Lateralis and Biceps Femoris, intramuscular coherence of the Tibialis Anterior,<br /><br>change in propulsion of the paretic leg, change in basic gait parameters,<br /><br>change in H-reflex of the Soleus, change in reciprocal Ia inhibition of the<br /><br>soleus and change in D2 inhibition at the post measurements compared to<br /><br>baseline.Other parameters are the leg portion of the Fugl Meyer score, the 10 m<br /><br>walk test, the Functional Ambulation Categories and the motricity index</p><br>