Modulation of Electrical Brain Responses by Nociceptive Stimulus Properties and Stimulus Detection: an Exploratory Study
Completed
- Conditions
- (chronische) pijn, perifere sensitisatie, centrale sensitisatiepain
- Registration Number
- NL-OMON44357
- Lead Sponsor
- MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Age between 18 and 40 years old.
Exclusion Criteria
* Participant refusal during the study.
* Language problems.
* Skin problems at site of stimulation or EEG recording.
* Diabetes.
* Implanted stimulation device.
* Pregnancy.
* Usage of analgesics within 24 hours before the experiment.
* Consumption of alcohol or drugs within 24 hours before the experiment.
* Pain complaints at the time of the experiment.
* A medical history of chronic pain.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Several types of nociceptive stimuli will be applied, while the subject*s<br /><br>response (detected or not detected) and the stimulus related EEG epochs will be<br /><br>measured. This data will be used for computation of a linear mixed-model<br /><br>describing the influence of stimulus parameters on the nociceptive evoked<br /><br>potential.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Analysis to determine if and how the EEG signal is dependent on stimulus<br /><br>properties like the inter-pulse interval, stimulus amplitude and stimulus<br /><br>detection.</p><br>