Influence of non-invasive electrical brain stimulation on explicit learning of a visuomotor fine motor task

Not Applicable

Recruiting

Conditions: visuomotor learning

Registration Number: DRKS00013044

Lead Sponsor: niversitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie im Neurozentrum, AG Neuroplastizität/Neuromodulation

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 144

Inclusion Criteria

Age between 18 and 85 years, explicit dominance of handedness (left- or right-hander according to Edinburgh Handedness Inventory 1971)

Exclusion Criteria

Severe chronic neurologic or psychiatric previous illness in anamnesis, current neurologic or psychiatric illness, not-corrigible defective vision, limited mobility of the upper extremity. Participants > 40 years: 24 or less points in the mini-mental-status test (MMSE), implanted medical devices (eg cochlear implant) or ferromagnetic objects (eg vascular clamps) in head and neck region.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
earning success at the end of the training day (day 1), measured as difference in reaction time and motor skill before, during and after Training, when performing the SVIPT paradigm (SVIPT = sequential visual isometric pinch force task). This will be measured for explicit learning (randomised training blocks) as well as implicit learning (last sequential training block compared to last random block).

Secondary Outcome Measures

Name	Time	Method
Single and group level analysis of secondary data: psychophysical data quantified daily (Days 1, 2 and 30) by standardized questionnaires Positive and Negative affect scale PANAS / Beck Depression inventory BDI as well as visual analogue scales for attention and subjective affection. MRI: structural data acquired once within the 30 days of participation in the study. Blood sampling for singular genetic analysis of polymorphisms in the gene for BDNF, COMT and ApoE. All parameters will be associated with the primary outcome, either by correlation or by their influence in a statistical regression model.