nderstanding the Neurobiology of Pharmacologically-induced Acute Stress on Ethical Decisions

Phase 1

• Conditions: Mimic an acute stress response in humans.; Therapeutic area: Psychiatry and Psychology [F] - Behavior and Behavior Mechanisms [F01]

• Registration Number: CTIS2023-508731-31-01
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-18
• Last Update Posted: 21 August 2024

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Age = 18 years and < 60 years old., Active duty military member.

Exclusion Criteria

Receiving current psychological treatment., Current or previous heart and/or vascular disease., Current or previous endocrine disease/endocrinal deficits., Use of recreational substances in the last four weeks., Medication use that interact with either yohimbine or hydrocortisone in the last week., Pregnancy, menstruation or contraceptives.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: The main objective of the trial is to observe the effects of yohimbine and/or hydrocortisone on moral judgement in military personnel.;Secondary Objective: The secondary objectives of the trial are the effects of yohimbine and/or hydrocortisone on working memory, impulse control, and risk taking in military personnel.;Primary end point(s): The number of utilitarian, deontological, and compromise choices made in a behavioural task measuring moral judgement., The number of violations in rationality when making moral decisions.

Secondary Outcome Measures

Name	Time	Method
Secondary end point(s):The total score of the forward, backward, and sequencing digit span of the Digit Span Task, an assessment of working memory.;Secondary end point(s):The stop signal reaction time of the Stop Signal Task, assessment of impulse control.;Secondary end point(s):The mean adjusted amount of button clicks and total number of exploded balloons for each risk condition in the Balloon Analogue Risk Taking task, assessment for risk-taking.