Effects of Cherry Consumption on Metabolic Health
- Conditions
- Metabolic Health
- Registration Number
- NCT07155915
- Lead Sponsor
- Instituto Politécnico da Guarda
- Brief Summary
This study is designed to evaluate the effects of daily sweet cherry consumption on markers of metabolic health in adults. Cherries are rich in bioactive compounds, such as anthocyanins and phenolic acids, which may help reduce oxidative stress, inflammation, and early risk factors for conditions like type 2 diabetes and cardiovascular disease. Participants will consume 280 grams of fresh sweet cherries every day for 42 consecutive days. Blood and urine samples will be collected at four time points: before the intervention (baseline), at day 21, at day 42 (end of the intervention), and two weeks after stopping cherry consumption.
The study will measure changes in blood sugar regulation, markers of inflammation, oxidative stress, liver and kidney function, and immune response. Waist circumference and body mass index will also be recorded.
The aim of this study is to test whether daily cherry consumption can support metabolic health in healthy adults and to provide data that may inform larger and longer clinical trials in the future.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 27
- Age 18-65 years old
- Healthy individuals with no known metaboli disorders
- Alcohol consumption
- Smoking
- Adverse or allergic reaction to cherries
- Use of antibiotics, anxiolytics, or dietary supplements
- Pregnancy or lactation
- Weight changes greater than 10% in the previous year.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Changes in fasting glucose Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in HbA1c Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in insulin Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in estimated average glucose Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in IL-6 Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in gluthatione reductase Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in AGP-1 Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in C-reactive protein Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in gluthatione peroxidase Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in glutamate dehydrogenase Baseline, Day 21, Day 42 and 2 weeks post-intervention
- Secondary Outcome Measures
Name Time Method Changes in LDL cholesterol Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in aspartate aminotransferase Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in alanine transaminase Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in gamma-glutamyl transferase Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in total bilirubin Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in conjugated bilirubin Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in unconjugated bilirubin Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in lactate dehydrogenase Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in total proteins Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in albumin Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in microalbumin Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in urea Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in creatinine Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in TIBC Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in transferrin Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in uric acid Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in iron Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in ferritin Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in amylase Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in lipase Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in IgA Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in IgG Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in HDL cholesterol Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in IgM Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in total IgE Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in rheumatoid factor Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in antistreptolysin O Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in triglycerides Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in total cholesterol Baseline, Day 21, Day 42 and 2 weeks post-intervention Changes in waist circumference Baseline and Day 42 Body Mass Index Baseline and Day 42
Trial Locations
- Locations (1)
Instituto Politécnico da Guarda
🇵🇹Guarda, Portugal
Instituto Politécnico da Guarda🇵🇹Guarda, Portugal