Endoscopic evaluation of surface distribution of different morphological forms of Nasya in healthy volunteers

This study was done in order to analyse the areasin nasal cavity tends to be affected during nasal administration of variousmorphological form of drugs and also to provide scientific approach to NasyaKarma, by means of endoscopic evaluation of nasal cavity done after Nasya.

For this purpose, 90 healthy volunteers wereregistered and divided into three groups i.e., 30 volunteers in each group,which then scrutinized by ENT department in order to check any rhino logicalpathology (if present). After examination the three groups were, Group A (inwhich nasal administration of lipid base nasal drops by using MadhuyashtyadiTail was done), Group B (in which aqueous form was administered intranasally byusing Madhuyashti Kwath) And Group C (in which nasal administration of powderwas done by using Madhuyashti Churna).

The excerpt of different morphological form ofNasya drug distribution pattern with special reference to different walls ofthe nasal cavity is reproduced here after as conclusion.

In the respiratory region (i.e., lateral wall,medial wall and floor)

The lateral wall was majorly occupied by lipid basenasal drops i.e., Madhuyastyadi Tail and powder form i.e., Madhuyashti Churna(both have same percentage i.e., 96.7%), and moderately by aqueous form i.e.,Madhuyashti Kwath (i.e., 70%).

The medial wall was considerably occupied by powderform (Madhuyashti Churna) (100%), moderately by aqueous form (MadhuyashtiKwath) (90.0%), and scarcely by lipid form (Madhuyashtyadi Tail) (63.3%).

The floor of nasal cavity was majorly occupied byMadhuyashti Churna (90.0%) and Madhuyashti Kwath (93.3%) and moderately byMadhuyastyadi Tail (76.7%).

According of above statements, the overallrespiratory region (i.e., lateral wall, medial wall and floor), was majorlyoccupied by Madhuyashti Churna, which means Churna or powder formulationsshould use intranasally in all that conditions in which systemic approach isneeded (as respiratory region is the highly vascularised area of nasal cavity).It can also use in conditions where immediate irritant effect is needed asmentioned by Acharya Charak in Sanyaas Chikitsa, Visha Chikitsa (24 treatmentmodalities of Acute poisoning mainly snake/insect bite).

As Madhuyashti Kwath majorly occupies medial wall,so aqueous base nasal drugs should be use in conditions related to medial walllike anterior epistaxis, as Acharya Charak has mentioned use of variousextracts in the treatment of Nasa-gata Raktapitta.

In the roof of nasal cavity i.e., Olfactory region

The Madhuyashtyadi Tail occupied olfactory areaconsiderably than the other form i.e., Kwath and Churna form, so oil basednasal preparations are used to target Centre Nervous System.