Role of Senescence in the Development of Endometrial Cancer
试验速览
- 阶段
- 不适用
- 发起方
- CHU de Reims
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- Genetic imbalances
研究概览
简要总结
Several molecular studies showed chromosomal alterations in patients with endometrial cancer, with gains in 1q, 19p, 19q, 8q, 10q and 10p and loss of 4q, 16q and 18q. Several genes of interest have been identified (P53, PTEN, PIK3CA, ß-catenin, K-ras ...).
A study has already been carried out at the Reims University Hospital with inclusion of patients with endometrial cancer and patients with endometrial hyperplasia. It identified specific alterations of nosologic continuum of pathology and characterize areas of interest on the genome.
详细描述
make a pangenomic investigation of genetic abnormalities in atypical endometrial hyperplasia and endometrial cancers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patient with endometrial hyperplasia or endometrial cancer
- •patient consenting to participate to the study
- •patient enrolled in the national healthcare insurance program
- •patient older than 18 years
排除标准
- •patient with neoadjuvant chemotherapy or radiotherapy prior to surgery
研究组 & 干预措施
Group "cases patients"
patients with endometrial hyperplasia or endometrial cancers
干预措施: Genetic analysis (Genetic)
结局指标
主要结局
Genetic imbalances
时间窗: Day 0
Genetic aberrations detected by comparative genomic hybridization (CGH arry)
次要结局
未报告次要终点