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Clinical Trials/NCT06129123
NCT06129123
Recruiting
N/A

Development of An Online, Theory-Based Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults: A Pilot Study

University of Southern California1 site in 1 country100 target enrollmentJuly 1, 2025

Overview

Phase
N/A
Intervention
Live Free From E-cigarettes
Conditions
E-cigarette Use
Sponsor
University of Southern California
Enrollment
100
Locations
1
Primary Endpoint
E-cigarette Use
Status
Recruiting
Last Updated
3 months ago

Overview

Brief Summary

The goal of this intervention development and pilot clinical trial is to determine whether receiving the brief online intervention results in greater reductions in past 7-day e-cigarette use frequency and smoking susceptibility over an 8-week period compared to receiving the control condition in young adults who currently use e-cigarettes. Participants in the experimental condition will be asked to complete the 30-minute mobile-based program. Participants in the assessment-only control will be given the option to access the intervention after they complete their final survey at 8 weeks. All participants will complete our online surveys at baseline as well as 2-weeks, 4-weeks, and 8-weeks post-randomization. Researchers will compare outcomes among the intervention and control groups to determine the efficacy of the intervention.

Registry
clinicaltrials.gov
Start Date
July 1, 2025
End Date
January 23, 2026
Last Updated
3 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Denise Tran

Assistant Professor

University of Southern California

Eligibility Criteria

Inclusion Criteria

  • be between the ages of 18 to 24
  • be able to read English
  • report vaping at least one day per week in the past month
  • report no history of cigarette use at screening and baseline.

Exclusion Criteria

  • reporting severe mental health, illicit drug use, or alcohol use disorder
  • currently receiving nicotine cessation services

Arms & Interventions

Intervention

Participants will be asked to complete a 30-minute intervention that is accessible on a mobile device, delivered via a webpage, and personalized to their individual vaping behavior and beliefs (based on the baseline surveys). The intervention will contain personalized normative feedback (PNF), Motivational Enhancement (ME), and education. Participants will complete assessments at baseline as well as 2-weeks, 4-weeks, and 8-weeks post randomization.

Intervention: Live Free From E-cigarettes

Waitlist Control

Participants will complete assessments at baseline as well as 2-weeks, 4-weeks, and 8-weeks post randomization. They will not receive the intervention during the active study phase, lasting 8 weeks. Participants will have the option to access the intervention once this active study phase is over.

Outcomes

Primary Outcomes

E-cigarette Use

Time Frame: 8 weeks

Participants will report the number of (1) days they vaped, (2) times they picked up their device to vape per day, and (3) puffs they took before putting their vaping device away per day in the past 7 days and 30 days

Smoking Susceptibility

Time Frame: 8 weeks

4-item Expanded Susceptibility to Smoking Index (ESSI)

Secondary Outcomes

  • Perceived harms and benefits of vaping(8 weeks)
  • Perceived harms and benefits of smoking(8 weeks)
  • Motivation to vape(8 weeks)
  • Motivation to smoke(8 weeks)
  • Quitting vaping self-efficacy(8 weeks)
  • Vaping quit attempts(8 weeks)

Study Sites (1)

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