99mTc-mebrofenin Hepatobiliary Scintigraphy (99mTc-HBS) liver function stress test.
Withdrawn
- Conditions
- lier failureliver insufficiency10019815
- Registration Number
- NL-OMON41103
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
Healthy volunteers.
Age 25-45 or *75 years.
Signed informed consent obtained prior to any study-specific procedure
Exclusion Criteria
Age <25 years or between 46-74 years.
Known with hepatic disease (e.g. cirrhosis, steatosis, cholestasis, hepatitis).
Underwent hepatic procedures in the past (e.g. portal vein embolization, radio frequent ablation, hepatic resection).
Treated with chemotherapy in the past.
Allergies/intolerance for the challenge agent (e.g. lactose or any other ingredients of the chocolate-milk).
Pregnancy or breastfeeding.
Not able to sign informed consent.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main objective of this study is to explore if hepatocytes have a functional<br /><br>reserve capacity:<br /><br><br /><br>- Does oral food challenge potentiate hepatic function measured with<br /><br>99mTc-mebrofenin HBS? </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary objective of this study is to explore if patient*s age influences<br /><br>the liver function and the hepatic reserve capacity:<br /><br><br /><br>- Does initial liver function measured with 99mTc-mebrofenin HBS differ between<br /><br>young and elderly patients?<br /><br>- Does liver function after oral food challenge measured with 99mTc-mebrofenin<br /><br>HBS differ between young and elderly patients?</p><br>