Hemodialysis-Induced Renal Perfusion Decline: Unraveling the Pathophysiological Mechanisms Linking Intradialytic Circulatory Stress to Residual Renal Function Loss
Active, not recruiting
- Conditions
- End-Stage Renal Disease Requiring Haemodialysis
- Registration Number
- NCT07003828
- Lead Sponsor
- Yuanjun Yang
- Brief Summary
Residual renal function (RRF) plays a critical role in quality of life and survival in hemodialysis (HD) patients but characteristically declines after the initiation of HD. Owing to incomplete understanding of the pathophysiology underlying RRF decline, protective strategies remain limited. The aim of this study was to characterize the changes in renal perfusion in incident HD patients with preserved RRF during dialysis sessions and to provide new strategies for RRF preservation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- (1) adult patients with end-stage renal disease (ESRD) within 3 months of commencing HD; (2) preserved RRF defined as urinary output >500 mL/24 h or eGFR ≥3 mL/min/1.73 m²
Exclusion Criteria
- (1) known allergy to sulfur hexafluoride microbubbles (SonoVue®) microbubbles; (2) vascular access dysfunction; (3) combined peritoneal dialysis; (4)severe cardiopulmonary disease; (5) active infection or malignancy; (6) communicable diseases; (7) pregnancy or breastfeeding; (8) participation in other clinical trials.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Renal perfusion at three time points during the HD session: pre-dialysis baseline, intradialytic phase (3 hours post-initiation) Renal perfusion was quantified using the CEUS-assessed perfusion index (PI). The primary outcome measure was the PI.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
the First Medical Center of Chinese PLA General Hospital
🇨🇳Beijing, China