Left Atrial Strain Assessment in Ischemic Stroke Patients

Completed

• Conditions: Ischemic Stroke; Left Atrial Strain; Sinus Rhythm

• Registration Number: NCT07102693
• Lead Sponsor: Connolly Hospital Blanchardstown

Brief Summary

This study is investigating a potential link between a novel measurement made on cardiac ultrasound and the risk of ischemic stroke in patients with a normal heart rhythm. The novel measurement is called left atrial strain. It uses speckle tracking echocardiography to measure the muscle function of the left atrium, one of the cardiac chambers. Investigators investigated whether patients with lower function of this chamber are at a higher risk of developing stroke from blood clots traveling to the brain. It is already known that patients with an irregular heart rhythm known as atrial fibrillation are at higher risk of these types of strokes. Investigators wanted to determine if there is a similar association in patients with normal heart rhythm but low left atrial strain.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-15
• Primary Completion: 2025-06-01
• Study Completion: 2025-06-01
• Study First Submitted: 2025-07-30
• Study First Submitted QC: 2025-07-30
• Status Verified: 2025-08
• Study First Posted: 2025-08-05
• Last Update Submitted: 2025-08-06
• Last Update Posted: 2025-08-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 468

Inclusion Criteria

• Emergency department presentation with FAST positive symptoms
• Neuroimaging performed as part of stroke workup
• Echocardiogram performed during index admission

Exclusion Criteria

• Any history of atrial fibrillation prior or during admission
• Age below 18 years of age
• No echocardiogram or echocardiogram images not of sufficient quality to perform left atrial strain analysis
• At least moderate mitral regurgitation
• ASD or PFO

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between left atrial strain and acute ischaemic stroke	2 weeks	This correlation will be adjusted for common stroke risk factors such as age, gender, hypertension, smoking, dyslipidaemia, and diabetes.

Trial Locations

Locations (1)

Connolly Hospital Blanchardstown; 🇮🇪 Dublin, Co. Dublin, Ireland