Left Atrial Strain Assessment in Ischemic Stroke Patients: a Retrospective Case-control Study - the ASSISTANT Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 468
- 试验地点
- 1
- 主要终点
- Correlation between left atrial strain and acute ischaemic stroke
研究概览
简要总结
This study is investigating a potential link between a novel measurement made on cardiac ultrasound and the risk of ischemic stroke in patients with a normal heart rhythm. The novel measurement is called left atrial strain. It uses speckle tracking echocardiography to measure the muscle function of the left atrium, one of the cardiac chambers. Investigators investigated whether patients with lower function of this chamber are at a higher risk of developing stroke from blood clots traveling to the brain. It is already known that patients with an irregular heart rhythm known as atrial fibrillation are at higher risk of these types of strokes. Investigators wanted to determine if there is a similar association in patients with normal heart rhythm but low left atrial strain.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Emergency department presentation with FAST positive symptoms
- •Neuroimaging performed as part of stroke workup
- •Echocardiogram performed during index admission
排除标准
- •Any history of atrial fibrillation prior or during admission
- •Age below 18 years of age
- •No echocardiogram or echocardiogram images not of sufficient quality to perform left atrial strain analysis
- •At least moderate mitral regurgitation
- •ASD or PFO
结局指标
主要结局
Correlation between left atrial strain and acute ischaemic stroke
时间窗: 2 weeks
This correlation will be adjusted for common stroke risk factors such as age, gender, hypertension, smoking, dyslipidaemia, and diabetes.
次要结局
未报告次要终点
研究者
Michael J Daly, MA MD PhD
Principal Investigator
Connolly Hospital Blanchardstown