Treatment of Nutritional rickets with different daily doses of oral vitamin D therapy
Not Applicable
- Conditions
- Health Condition 1: E550- Rickets, active
- Registration Number
- CTRI/2023/05/053097
- Lead Sponsor
- Society of endocrine healthcare of elderly, adolescents and children
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Children aged 12-60 months with a diagnosis of nutritional rickets defined by clinical, biochemical and radiological parameters (radiology severity score =2.5).
Exclusion Criteria
1. Patients with confirmed or suspected diagnosis of malabsorption or chronic kidney or hepatic disease.
2. Patients with severe systemic illness compromising oral intake (tachycardia, tachypnea, shock, weak peripheral pulses, increased capillary refill time).
3. Patients who have taken supra-physiological dose of vitamin D (more than 800 IU/day) in last 6 months.
4. Children with hypercalcemia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of children who achieve complete radiological healing (defined as radiological score = 1.5)Timepoint: Baseline and 12 weeks
- Secondary Outcome Measures
Name Time Method 1)Increase in serum 25(OH) D, 1,25(OH)D at 12 weeks <br/ ><br>2)Decline in PTH and CTX level at 12 weeks <br/ ><br>3)Decline in ALP level at 12 weeks. <br/ ><br>4)Proportion of children with severe vitamin D deficiency (serum 25OHD 12ng/mL)Timepoint: 12 weeks