Evaluation of a synergy effect on human intestinal condition with taking combination of wheat bran fiber and Barley Max in a randomized double blind study
- Conditions
- 1.Defecation frequency: less than 5times/week 2.The people who have a low intake of fiber (lower than 12g/day by simple dietary record for 4 days (3 days in weekday and 1 day in weekend).
- Registration Number
- JPRN-UMIN000027569
- Lead Sponsor
- Seiichiro Aoe Otsuma Womens University Faculty of Home Economics Department Food Science
- Brief Summary
In the present study, we investigated which of these two fiber sources would produce more favorable changes in the fecal variables of healthy subjects. Sixty healthy subjects were randomly divided into four groups (n = 15 per group) and fed twice daily for 4 weeks with baked cereal bars containing neither WB nor BM (WB-BM-), WB without BM (WB+BM-), BM without WB (WB-BM+), or WB and BM (WB+BM+). At baseline and after 4 weeks, the fecal microbiota composition and the concentrations of short-chain fatty acids were measured. A significant interactive effect of WB and BM on the abundance of genus Bacteroides was observed at week 4. The abundance of butyrate-producing bacteria and the fecal concentration of n-butyrate were significantly higher in the WB+ groups than in the WB- groups. In conclusion, WB was associated with elevated fecal concentrations of short-chain fatty acids including butyrate owing to an increase in the abundance of butyrate-producing bacteria. Additionally, the combination of WB and BM was associated with an increase in the abundance of genus Bacteroides. Therefore, both WB alone and WB combined with BM favorably influenced the fecal variables of healthy subjects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Not provided
Same as Jpn Pharmacol Ther.44,1785 (2016) 1.The person who uses a medicine for intestinal disorders and aperient (including the laxative) regularly 2.The person who uses health foods told to be good for constipation improvement at the time of screening examination (including the food for specified health use) regularly 3.The person who takes a drug affecting the digestion and absorption including the antibiotic at the time of screening examination 4.The person who cannot stop raw fungal inclusions such as a lactic acid bacterium, a bifidus bacillus, the Bacillus natto, the food which strengthened an oligosaccharide, a dietary fiber, a health food (including the food for specified health use) said to that it is good for constipation improvement and sugar alcohol large quantity component food, the barley-rich food, the intake of the supplement all over the study time 5.Person having food allergy 6.A person infected with a disease to urgently need treatment or person having serious complications 7.Person with a history of a digestive organ disease to affect the digestion and absorption and the bowel movement or the operation 8. It was judged the answer to subject background questionnaire to be inappropriate as a subject (the plan that greatly changes includes life events all over the study time) 9. Person whom it was judged a blood test with the screening examination to be inappropriate as a subject. E.g. Person who have some kind of diseases. 10. Pregnant person, person with the intention of the pregnancy during the study time, the person whom I am nursing 11. Person with drug dependency, an anamnesis of alcohol dependence or the existing medical history 12. Person participating in an examination to apply an intake of other food and the examination using the drug, cosmetics and a drug, person with the intention of the participation 13. Others. the person who judged an examination responsibility doctor to be inappropriate as a subject
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method