How does pneumatic tube transportation of thrombocyteconcentrates for transfusion purposes influence the thrombocyte in vivo function?

Recruiting

• Conditions: lack of bloodplatelets; thrombocytopenia; 10035534

• Registration Number: NL-OMON55358
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 48

Inclusion Criteria

thrombocytopenia (<10 x 109/L) with an indication for prophylactic platelet
transfusion
adults
informed consent

Exclusion Criteria

Infection and sepsis, active bleeding, splenomegaly
Treatment with anticoagulants (LMWH, acetylic acid, coumarines)
Thrombocyte transfusion shorter than 72 hours ago
Temperature above 37.9 degrees Celsius

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Increment of transfuion after 1 and 24 hours (measured by number of<br /><br>thrombocytes and corrected ammount increment-CCI)<br /><br>Differences of<br /><br>Mean platelet volume (MPV)<br /><br>Whole blood impedance measurement (activated by ADP/TRAP/COLL/ASPI)<br /><br>CD62<br /><br>Microparticles<br /><br>PFA-100<br /><br>Thrombelastography (for fibrinolysis)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Incidence of spontaneous bleeding irrespective TC transfusion.</p><br>