Study to check the efficacy of Buprenorphine Patch 10mg in controlling the Blood Pressure and Heart Rate that increases in response to introduction of Laryngoscope and Endotracheal Tube into the airway in patients undergoing Surgery under General Anesthesia

Not yet recruiting

Conditions: Measurement and Monitoring, (2) ICD-10 Condition: 4||Measurement and Monitoring,

Registration Number: CTRI/2022/09/045432

Lead Sponsor: Mahatma Gandhi University Of Medical Sciences And Technology

Brief Summary: Altered hemodynamic response during laryngoscopy and intubation can cause many complications like left ventricular failure,myocardial infarction and pulonary edema etc.Oral or iv intravenous medications used to prevent stress response have been associated with many undesirable adverse effects like respiratory depression,drowsiness ,nausea and vomiting etc.Rationale for study is that transdermal buprenorphine would attenuate the stress response with no or minimal side effects.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

1.Patient posted for surgery under general anaesthesia 2.
patient with American Society of anaesthesiologists (ASA) Class I and II 3.
patient of any sex (male or female) aged between 18-60 years 4.
patient who give consent to involve in study.

Exclusion Criteria

ï‚·Patient with American Society of Anaesthesiologists (ASA) Class III and IV ï‚·Patient allergic to buprenorphine ï‚·Patients with anticipated difficult intubation (Modified mallapatti score 3 or more) 1.More than one attempt at intubation 2.When intubation time exceeds 30 seconds 3.Patients with severe cardiopulmonary compromise 4.Pregnant female 5.Patients with liver and kidney disease 6.Patient refusal.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to observe any changes in systolic blood pressure after laryngoscopy and intubation.	preoperatively and postoperatively

Secondary Outcome Measures

Name	Time	Method
to observe changes in diastolic blood pressure,mean areterial pressure, and ecg	preoperatively and intraoperatively

Trial Locations

Locations (1): Mahatma Gandhi Hospital
🇮🇳
Jaipur, RAJASTHAN, India
Mahatma Gandhi Hospital
🇮🇳Jaipur, RAJASTHAN, India
Dr Preetika Dhall
Principal investigator
8396007347
preet25dhall@gmail.com