Early Infectious Disease Consultations in Staphylococcus Aureus Bacteremia

Not Applicable

• Conditions: Staphylococcus Aureus Bacteremia
• Interventions: Other: infectious disease specialist consultation

• Registration Number: NCT00622882
• Lead Sponsor: National University Hospital, Singapore

Brief Summary

The primary objective is to determine if early infectious disease (ID) consultation (defined as within 48 hours of a positive blood culture) will reduce mortality rates from Staphylococcus aureus bacteremia (SAB). This study will also determine if such consultations could reduce the duration of hospitalisation, recurrence and financial costs in patients with this infection.

Detailed Description

Bacteremia is a serious manifestation of Staphylococcus aureus infection with an attributable mortality as high as 25% in MRSA bacteremia. More than a third of patients end up with complications such as endocarditis, osteomyelitis or pneumonia.

Overall the outcome of patients with respect to mortality or recurrence is better in patients who have an eradicable focus and have received an appropriate antibiotic dose and duration. Also complicated bacteremia is more common in patients with

* persistent bacteremia or fever

* prosthetic device

* new murmur

* skin findings of a systemic infection

Based on this evidence, an ID consultation could improve the outcomes of patients with SAB by

* Advising adequate antibiotic dosage and duration

* Sourcing out and counselling eradication of any focus of infection

Study Timeline

• Study Start: 2007-10
• Study First Submitted: 2008-02-13
• Study First Submitted QC: 2008-02-22
• Study First Posted: 2008-02-25
• Status Verified: 2014-01
• Last Update Submitted: 2014-01-06
• Last Update Posted: 2014-01-07
• Primary Completion: 2015-12
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• All inpatients at the National University Hospital with Staphylococcus aureus (both methicillin sensitive and methicillin resistant) bacteremia isolated within the defined time period

Exclusion Criteria

• Patients who died or were discharged before the notification from the laboratory
• Neonates
• Polymicrobial bacteremia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ID	infectious disease specialist consultation	Patients receiving an early Infectious disease consultation ( within first 48 hours of a positive blood culture)

Primary Outcome Measures

Name	Time	Method
mortality	1 year

Secondary Outcome Measures

Name	Time	Method
recurrence	2 year
duration of hospitalisation	1 year
financial costs of hospitalisation	1 year

Trial Locations

Locations (1)

National University Hospital; 🇸🇬 Singapore, Singapore