Early Infectious Disease Consultation for Better Outcomes From Staphylococcus Aureus Bacteremia
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- mortality
研究概览
简要总结
The primary objective is to determine if early infectious disease (ID) consultation (defined as within 48 hours of a positive blood culture) will reduce mortality rates from Staphylococcus aureus bacteremia (SAB). This study will also determine if such consultations could reduce the duration of hospitalisation, recurrence and financial costs in patients with this infection.
详细描述
Bacteremia is a serious manifestation of Staphylococcus aureus infection with an attributable mortality as high as 25% in MRSA bacteremia. More than a third of patients end up with complications such as endocarditis, osteomyelitis or pneumonia.
Overall the outcome of patients with respect to mortality or recurrence is better in patients who have an eradicable focus and have received an appropriate antibiotic dose and duration. Also complicated bacteremia is more common in patients with
- persistent bacteremia or fever
- prosthetic device
- new murmur
- skin findings of a systemic infection
Based on this evidence, an ID consultation could improve the outcomes of patients with SAB by
- Advising adequate antibiotic dosage and duration
- Sourcing out and counselling eradication of any focus of infection
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 1 Month 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All inpatients at the National University Hospital with Staphylococcus aureus (both methicillin sensitive and methicillin resistant) bacteremia isolated within the defined time period
排除标准
- •Patients who died or were discharged before the notification from the laboratory
- •Polymicrobial bacteremia
结局指标
主要结局
mortality
时间窗: 1 year
次要结局
- recurrence(2 year)
- duration of hospitalisation(1 year)
- financial costs of hospitalisation(1 year)
研究者
Medicine
Professor Paul Ananth Tambyah
National University Hospital, Singapore