NL-OMON47599招募中不适用
Characterization of platelets and antibodies in adult patients with immune thrombocytopenia (ITP) - Research into the development of ITP
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Patients receiving corticosteroids, IVIG or TPO receptor agonists are allowed to participate. ;- Age minimal 18 years, both men and women
- •- Subjects with primary/chronic ITP (as defined by [Rodeghiero] with platelet numbers that have been below <30*10^9/L at one timepoint)
- •- Written informed consent
- •- WHO performance status <3
排除标准
- •- Prior treatment with rituximab as this will interfere with B-cell isolation
- •- Use of anticoagulants (e.g. NSAIDs) affecting platelet function
- •- Inadequate renal and liver function, i.e. creatinine or bilirubin >2.5 x the upper normal value
- •- Severe cardiac dysfunction
- •- Severe pulmonary dysfunction
- •- Severe neurological or psychiatric disease
- •- Any psychological, familial, sociological and geographical condition potentially hampering compliance with the study protocol
- •- Concurrent severe and/or uncontrolled medical condition (e.g. uncontrolled diabetes, hypertension, cancer, etc.)
- •- Neutrophil count <1.5*10^9/L and hemoglobin level <6.2 mmol/L.
- •- Active bleeding (defined by grade 3 or 4 according to NCI CTCAE v3.0)
- •- Pregnant or lactating
- •- Systemic infections: active viral infections, including HIV
- •- Seriously immunocompromised patients
- •- Systemic autoimmune disorders (e.g. systemic lupus erythematosus, SLE)
- •- Current malignant disease
- •- Any experimental therapy within 30 days prior to blood draw
研究者
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