A Comparison between Dexmedetomidine and Remifentanil for rigid Bronchoscopic Pulmonary Procedures A Randomized Controlled Trial
试验速览
- 阶段
- 2/3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- The change in hemodynamic variables between
研究概览
简要总结
As a subspecialty of Pulmonary medicine, interventional bronchoscopy has been developing in recent years. Various bronchoscopic procedures include foreign body removal, rigid bronchoscopy, tracheal dilation, Endobronchial ultrasound (EBUS), biopsy of mass etc.
For lung neoplasms, it offers minimally invasive Palliative and therapeutic procedures. In lung cancer cases, the interventional bronchoscopy role has been elevated from “diagnosis priority†to “diagnosis and treatment developed togetherâ€. Palliative therapy with bronchoscopy for lung cancer eases dyspnea, relieves airway obstruction, prolongs the survival and improves the quality of life.
Bronchoscopy also plays an important part in the periop period. In the preoperative localization of peripheral pulmonary nodules, the management of tracheoesophageal fistula (TEF)/bronchoesophageal fistula (BEF), and postoperative bronchopleural fistula (BPF), which are complications of lung cancer, Bronchoscopy plays a role.
Rigid bronchoscopy requires some form of anesthesia and various drugs are used for anesthesia. In our study we aim to compare Dexmedetomidine vs remiferntanil with general anesthesia with respect to hemodynamic parameters, postoperative recovery, ponv, cough, and any complications in between the drugs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Age between 18 to 80 years of age and American Society of Anesthesiologists (ASA) Physical Status Class I, II and III.
- •2.Patients undergoing rigid bronchoscopic procedures.
- •3.Patients giving consent for the procedure.
排除标准
- •Severe renal, hepatic or heart failure
- •heart blocks 4.severe obesity
- •allergy to any medications 6.refusal to give consent 7.pregnancy 8.Procedure that takes more than 2 hours.
结局指标
主要结局
The change in hemodynamic variables between
时间窗: Baseline, during rigid bronchoscopy, every 5minutes after that till bronchoscopy is complete. | 5, 10, 15, 30 minutes, 1hour, 2 hours, 4 hours, and 6 hours postop
the groups during rigid bronchoscopy.
时间窗: Baseline, during rigid bronchoscopy, every 5minutes after that till bronchoscopy is complete. | 5, 10, 15, 30 minutes, 1hour, 2 hours, 4 hours, and 6 hours postop
次要结局
- The time needed for patients to meet(postanesthesia care unit discharge criteria)
- nausea/vomiting(till 6hrs postop)
- postop cough(till 6hrs postop)
- time taken for BIS score to reach 80(till 6hrs postop)
- Post-op Sore throat(till 6hrs postop)
研究者
Muralidhara P
All India Institute Of Medical Sciences- New Delhi