A Prospective Randomized Comparative Study to Compare the Efficacy of Intratracheal Dexmedetomidine versus Intravenous Dexmedetomidine in Attenuating Periextubation Cough and Hemodynamic Stress Response during Tracheal Extubation under General Anaesthesia

A study to compare the efficacy of intra tracheal dexmedetomidine versus intravenous dexmedetomidine in attenuating peri extubation cough and hemodynamic responses during tracheal extubation under general anaesthesia

Objective is to study the efficacy of attenuating peri-extubation cough using 4 point cough scale during tracheal extubation,To stud the post operative sedation score, to study the haemodynamic stress responses during extubation, To study the duration of analgesia by Visual Analogue Score (VAS) score and side effects if any

Inclusion criteria

•Patients voluntarily willing to sign written & informed consent.

•Male or female patients between age group of 18 to 60 years of age.

•Patients belonging to American Society of Anesthesiologists (ASA) physical status I and II.

•Patients posted for elective surgeries under general anaesthesia.

Exclusion criteria

•Patients unwilling to participate in the study.

•Patients with American Society of Anaesthesiologists (ASA) physical status III,

IV

•Patients with Body Mass Index ≥ 30 kg/m2

•Patients with anticipated difficult airway & intubation.

•Patients with preexisting hoarseness or sore throat or URTI.

•Patients with cardiovascular disease, arrhythmias, heart blocks, or taking beta

blockers or any antihypertensive treatment.

•Patients with cerebrovascular, hepatic and renal disease.

•Patients using steroids or having history of asthma or COPD.

•Patients with history of allergy to an α-2 adrenergic agonist.

Pregnancy & lactating women

Site of studyS.B.K.S. Medical Institute and Research Centre, Sumandeep Vidhyapeeth University, Piparia, Vadodara, Gujarat

Study design  observational comparative study

Study Duration: The study will be initiated after obtaining permission from institutional ethics  committee till the achievement of the sample size or by 18 months whichever is earlier.

Data will be collected & tabulated. Numerical variables will be presented as mean & standard deviation (SD) while categorical variables will be presented as frequency and percentage. As regard to numerical variables; tests like unpaired student–t test and/or ANNOVA will be used whenever appropriate for between-groups comparisons, while for categorical variables, chi–square test will be used. P value<0.05 will be considered statistically significant.

**Likely outcome/ Benefit :**This prospective comparative study will help us to compare the efficacy between intratracheal dexmedetomidine and intravenous dexmedetomidine in attenuating peri extubation cough and hemodynamic stress responses to tracheal extubation in patients undergoing surgeries under general  anaesthesia and will enable us to know which route of the dexmedetomidine drug is most beneficial in giving balanced general anaesthesia by having better outcomes in cough reflexes and hemodynamics and less post operative complications