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Clinical Trials/NCT00431535
NCT00431535
Completed
Not Applicable

Descriptive Study Concerning the Connection Between SvO2 and Orthostatic Function Post Operatively

Rigshospitalet, Denmark2 sites in 1 country17 target enrollmentFebruary 2007
ConditionsSurgery

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Surgery
Sponsor
Rigshospitalet, Denmark
Enrollment
17
Locations
2
Status
Completed
Last Updated
12 years ago

Overview

Brief Summary

It is the purpose of the investigators to investigate the possible relationship between fall in the amount of Oxygen in the blood and disturbances of balance-function before and after surgery.

Detailed Description

It has been shown that the mixed venous saturation (SvO2) is usable as a parameter of fluid status. It has also been suggested that there is a connection between SvO2 and blood flow in tissue , and that a SvO2 of less than 40% is a sign of tissue hypoxia. Recently it has been shown that patients going through heart surgery experience a drop in SvO2 during early mobilization.This drop lasts throughout the mobilisation process. We want to investigate whether the same mechanism applies to patients going through other types of surgery, and whether there is a connection between a drop in SvO2 and orthostatic function. This will be done by making 3 tests. One pre-operatively,one six hours post-operatively and one 18-24 hours after surgery. The tests will consist of: 1. 10 min of rest. 2. 3 min of sitting upright on the side of the bed. C. 3 min of standing on the floor. D. 10 min of rest. Between each position a venous blood sample will be taken. Also 1 blood sample will be taken at the end of surgery. Continuous measurements by the Finapres system wil be made throughout the test-sequence to investigate changes in BP, SV, TPR and HR. At the same time the patient will be pain-scored when taking a new position.

Registry
clinicaltrials.gov
Start Date
February 2007
End Date
May 2007
Last Updated
12 years ago
Study Type
Observational
Sex
Male

Investigators

Eligibility Criteria

Inclusion Criteria

  • Patients going through Radical Prostatectomy, where CVC is standard.

Exclusion Criteria

  • Non informed consent
  • ASA \> II
  • Age less than 18, or more than 80 years
  • Diabetes Mellitus
  • Epidural analgetics
  • Alcohol abuse (investigators assessment)
  • Unable to understand written or spoken information
  • Using beta-blockers

Outcomes

Primary Outcomes

Not specified

Study Sites (2)

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