A Better Understanding of the Association Between Problem Gambling and Psychotic Disorders in Young Adults: a New Path Towards Recovery
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Laval University
- Enrollment
- 520
- Locations
- 2
- Primary Endpoint
- Problem gambling
Study Overview
Brief Summary
The aims of this propsective cohort study are to get a better understanding of the association between problem gambling and psychotic disorders among young adults with first-episode psychosis.
The main questions to be answered are:
- What is the incidence of problem gambling in this population?
- What are the predictors of problem gambling in this population?
To do so, putative predictors of problem gambling will be analyzed using Cox regression models:
- Sociodemographics (e.g., age, gender identity, ethnicity, level of education, employment);
- Psychiatric comorbidities (e.g., substance use disorders, cluster B personality disorders);
- Antipsychotic use (first/second-generation, third-generation [aripiprazole, brexpiprazole, cariprazine]);
- Prior gambling history.
Detailed Description
All Cox regression models will be adjusted for site-effect. Further multivariable models will be constructed to examine the association between antipsychotic use (as continuous exposure) and incident PBG using the directed acyclic graphs approach to adjust for confounders.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •18 to 35 years old;
- •Diagnosis of first-episode psychosis (i.e., DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders, as well as DSM-5 bipolar disorder with psychotic features).
Exclusion Criteria
- •Active/prior PBG at te time of admission;
- •Loss to follow-up within first three months;
- •DSM-5 diagnosis of psychotic disorder due to a medical condition;
- •Severe intellectual disability.
Arms & Interventions
First-episode psychosis patients
All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.
Intervention: Antipsychotic use (Drug)
First-episode psychosis patients
All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.
Intervention: Psychiatric comorbidities (Other)
First-episode psychosis patients
All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.
Intervention: Sociodemographics/socioeconomic status (Other)
First-episode psychosis patients
All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.
Intervention: Gambling history (Other)
First-episode psychosis patients
All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.
Intervention: Clinical variables (Other)
Outcomes
Primary Outcomes
Problem gambling
Time Frame: Outcome assessed at every 6-month time point, from patients admission until the first occurrence of the primary outcome, loss to follow-up, or May 1, 2023.
i) Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist, and/or; ii) Problem gambling according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager and/or treating psychiatrist
Secondary Outcomes
No secondary outcomes reported
Investigators
Olivier Corbeil
PharmD, MSc, Pharmacist, Principal Investigator
Laval University