How Does Disease Severity, Object Weight, Object Friction, and Sudden Changes to Object Weight Affect Precision Pinch Grip Force in Carpal Tunnel Syndrome?
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Change in Precision Pinch Grip Force measured during a pinch-hold up activity over time during follow-up
研究概览
简要总结
INTRODUCTION Carpal tunnel syndrome (CTS) is a common condition that results in impaired hand function. In cases of CTS the "pinch grip" force between the thumb and index finger becomes unnecessarily high to prevent objects from slipping when they are picked up.
HYPOTHESES The proposed study will investigate the following hypotheses regarding CTS.
As an object is picked up, the investigators suspect there will be several points at which grip force will be different between patients with different severities of CTS, i.e. grip may deteriorate as CTS gets worse.
The investigators also suspect grip force will be affected depending on the weight of the object, i.e. patients with CTS may struggle with objects of a certain weight.
Patients with CTS sweat less, and this may affect their grip. The investigators suspect that pinch grip in CTS patients is disproportionately altered by the frictional properties of the object and by the moistness of the skin.
The investigators suspect patients with CTS will be less able to adapt to sudden changes in an object's weight.
The investigators wish to examine how the above are affected after surgical treatment of CTS.
METHODS The investigators will include patients with symptomatic, idiopathic CTS, aged between 18 and 80 years. The investigators' centre will recruit CTS patients who will attend their National Health Service (NHS) outpatient appointment followed by nerve conduction studies. An equal number of healthy participants will be recruited for comparison purposes.
At the aforementioned appointment, patients will undertake a pinch grip force test using a device that will test the above points.
Patients will have normal care under their surgeon, which may include an operation for treatment of CTS. Therefore some patients will be invited back to have grip tests again after their operation. No aspect of the study will prevent a patient from receiving their normal National Health Service (NHS) care.
详细描述
RESEARCH QUESTIONS
This study will ask important questions about CTS that builds on previous research in the field. The research questions are:
- How is precision pinch grip force affected by CTS throughout the activity of picking up and replacing an object, for a range of CTS severities, especially in more severe CTS?
- How is precision pinch grip force affected in patients with CTS when picking up objects of different weights?
- How is precision pinch grip force affected in patients with CTS when the frictional properties of the skin-device interface are altered?
- How does precision pinch grip force in CTS alter after a sudden increase in downward load force?
- How do these parameters change after surgical treatment of CTS?
CLINICAL IMPLICATIONS AND STUDY JUSTIFICATION Answers to the above questions will inform understanding of both precision pinch grip force control, and CTS.
Patients with CTS drop things, and the investigators feel that impaired hand function in CTS is related to poor grip control.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Central neurological or psychiatric disease Visual impairment or any other impairment that would interfere with the patient's ability to perform the study tests Pregnant patients. (Criteria based on prior research (Zhang et al. 2011)).
- •Control population is as previously specified.
结局指标
主要结局
Change in Precision Pinch Grip Force measured during a pinch-hold up activity over time during follow-up
时间窗: Assessed at initial outpatient appointment, at 3, 6 and 12 months
Precision pinch grip force will be measured over time during a pinch-hold up activity. Change in this force will be observed over time at 3, 6 and 12 months follow-up.
次要结局
未报告次要终点
研究者
Thomas Edward Pidgeon
Chief Investigator
University Hospital Birmingham NHS Foundation Trust