STUDY OF VARIATION IN OPRM1 Al18G AND ITS CORRELATION WITH DIFFERENCE IN THE INCIDENCE of NAUSEA VOMITING AFTER FEMUR FRACTURE SURGERY IN PATIENTS RECEIVING TRAMADOL FOR PAIN RELIEF
Not Applicable
Completed
- Conditions
- Health Condition 1: M959- Acquired deformity of musculoskeletal system, unspecified
- Registration Number
- CTRI/2021/09/036433
- Lead Sponsor
- niversity College of Medical Sciences and GTB Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA physical status I or II undergoing isolated femur fracture surgeries under spinal anaesthesia
Exclusion Criteria
history of significant cardiac, hepatic or renal disease; Patients having nausea or vomiting 24 hours before surgery and/or those receiving any other antiemetics within last 24 hour and a known hypersensitivity to 5HT3 agents
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To correlate PONV score amongst different specific OPRM1 A118G allele groupsTimepoint: Baseline venous blood sample for gene polymorphism study before the surgery
- Secondary Outcome Measures
Name Time Method To assess the incidence of nausea and vomiting amongst different specific OPRM1 A118G allele groupsTimepoint: Baseline venous sample for gene polymorphism study before the surgery