Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:
Terminated
- Conditions
- Paget's DiseaseOsteosarcoma
- Registration Number
- NCT00615628
- Lead Sponsor
- State University of New York - Upstate Medical University
- Brief Summary
Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.
- Detailed Description
As above, no additional information
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 8
Inclusion Criteria
- This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18.
- The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.
Exclusion Criteria
- Not part of the family
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Loss of heterozygosity January, 2000 through February 2009 A loss of heterozygosity of a proposed tumor suppressor gene on chromosome 18
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
SUNY Upstate Medical University
🇺🇸Syracuse, New York, United States