The Importance of Sleep Quality and the Blood-brain Barrier in Cognitive Disorders and Alzheimer's Disease
- Conditions
- Sleep DeprivationAlzheimer DiseaseBlood Brain Barrier DefectSleep Apnea
- Interventions
- Diagnostic Test: Diagnostic Test
- Registration Number
- NCT04096261
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
The aim of our study is the analysis of sleep phases and quality as well as the detection of respiratory pauses in subjects with cognitive disorder. To assess whether sleep quality is associated with the blood-brain barrier and Alzheimer's disease, which may be indicative of an early, non-invasively measurable change in brain activity in the early stages of Alzheimer's disease.
- Detailed Description
The aim of our study is the analysis of sleep phases and quality as well as the detection of respiratory pauses in subjects with cognitive disorder. To assess whether sleep quality is associated with the blood-brain barrier and Alzheimer's disease, which may be indicative of an early, non-invasively measurable change in brain activity in the early stages of Alzheimer's disease.
Sleep quality impairment is a known risk factor for memory impairment. There is increasing evidence of a link between measurable sleep parameters, in particular a reduction of slow waves of deep sleep in cognitive deficits. Also, breathing pauses during sleep are associated with increased daytime sleepiness and cognitive impairment. This observational study is intended to establish a possible link between subjective memory disturbances and altered sleep quality or respiratory breaks during sleep. In the run-up to this study, they performed a special MRI scan of the head and a lumbar puncture (removal of nerve water) in a different context. The aim of this imaging study and the new biomarker in brain water was to investigate the function of the blood-brain barrier that occurs in Alzheimer's disease. The results of the studies on the quality of sleep should be evaluated in the context of this study in connection with the findings of the MRI examination and lumbar puncture.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Subjective cognitive decline Diagnostic Test Individuals who subjectively experience cognitive decline but do not show deficits in age-, sex- and education-normed neuropsychological test results. Those individuals are part of the DELCODE cohort and were initially recruited in a memory clinic. Mild cognitive impairment Diagnostic Test Individuals who show deficits in neuropsychological test procedures but who do not exhibit substantial problems in daily life. Those individuals are part of the DELCODE cohort and were initially recruited in a memory clinic. Siblings of people with Alzheimer's dementia Diagnostic Test Siblings of people with Alzheimer's dementia recruited through public advertisement Dementia due to Alzheimer's disease Diagnostic Test Individuals diagnosed with dementia due to Alzheimer's disease by relying on anamnesis, neuropsychological test results, results of MRI and biomarkers found in the cerebrospinal fluid. Those individuals are part of the DELCODE cohort and were initially recruited in a memory clinic. Healthy controls Diagnostic Test Healthy controls recruited through public advertisement.
- Primary Outcome Measures
Name Time Method Marker of blood-brain dysfunction using MRI 1 day Dynamic T1 contrast enhanced sequence using Gadovist
Markers of blood-brain dysfunction using CSF 1 day Platelet-derived growth factor receptor-β in CSF
Sleep quality measurement 2 day Polysomnography
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Charité Universitätsmedizin Berlin
🇩🇪Berlin, Germany