NL-OMON55454
Recruiting
Not Applicable
Imaging in motor neuron diseases; biomarker research with MRI - Imaging in MND
niversitair Medisch Centrum Utrecht0 sites2,203 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversitair Medisch Centrum Utrecht
- Enrollment
- 2203
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1a) Patients: i) For ALS patients: definite, probable, probable\-laboratory
- •supported or possible ALS according to the revised El Escorial criteria (Brooks
- •2000\); familial ALS is defined only if there is a family history of ALS. ii)
- •For progressive spinal muscular atrophy (PSMA) or primary lateral sclerosis
- •(PLS): patients with clinical diagnosis of PSMA or PLS, after excluding other
- •diseases. iii) Patients with \*ALS mimic syndromes\*: patients suspected of /with
- •mimic disorders (e.g. multifocal motor neuropathy, inclusion body myositis,
- •cervical myeloradiculopathy, myasthenia gravis, Kennedy\*s disease, spinal
- •muscular atrophy).
- •1b) Healthy controls without manifest diagnosis of motor neuron disease or ALS
Exclusion Criteria
- •1\) Tracheostomy, tracheostomal ventilation of any type, (non)\-invasive
- •ventilation; 2 ) Any history or presence of brain injury, epilepsy, psychiatric
- •illness and other cerebral disease; 3\) Any intoxication or medication known to
- •have an association with motor neuron dysfunction, which might confound or
- •obscure the diagnosis of motor neuron disease; 4\) Presence of pronounced
- •swallowing disorders (which make it dangerous to lie supine in the MRI
- •scanner); 5\) Contra\-indication for 3Tesla MRI imaging (as established by the
- •radiology department); 6\) Pregnancy
Outcomes
Primary Outcomes
Not specified
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