NL-OMON35176
Withdrawn
Not Applicable
Imaging in motor neuron diseases; biomarker research with MRI - Imaging in MND
niversitair Medisch Centrum Utrecht0 sites900 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- motor neuron disease (MND)
- Sponsor
- niversitair Medisch Centrum Utrecht
- Enrollment
- 900
- Status
- Withdrawn
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Patients: i) For ALS patients: definite, probable, probable\-laboratory supported or possible ALS according to the revised El Escorial criteria (Brooks 2000\); familial ALS is defined only if there is a family history of ALS. ii) For progressive spinal muscular atrophy (PSMA) or primary lateral sclerosis (PLS): patients with clinical diagnosis of PSMA or PLS, after excluding other diseases. iii) Patients with \*ALS mimic syndromes\*: patients suspected of mimic disorders (e.g. multifocal motor neuropathy, inclusion body myositis, cervical myeloradiculopathy, myasthenia gravis,
- •Kennedy\*s disease). 2\. Age 18 \- 80 years (inclusive). 3\. Capable of thoroughly understanding the study information given; has signed the informed consent.
Exclusion Criteria
- •1\) Tracheostomy, tracheostomal ventilation of any type, (non)\-invasive ventilation; 2 ) Any history or presence of brain injury, epilepsy, psychiatric illness and other cerebral disease; 3\) Any intoxication or medication known to have an association with motor neuron dysfunction, which might confound or obscure the diagnosis of motor neuron disease; 4\) Presence of pronounced swallowing disorders (which make it dangerous to lie supine in the MRI scanner); 5\) Contra\-indication for 3 or 7Tesla MRI imaging (as established by the department); 6\) Pregnancy
Outcomes
Primary Outcomes
Not specified
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