Marker Assisted Selective ThErapy in Rare Cancers: Knowledge Database Establishing registrY Asia

Recruiting

• Conditions: Rare Malignant Neoplasm

• Registration Number: NCT05217407
• Lead Sponsor: National Cancer Center, Japan

Brief Summary

This is a registry study that aims to collect patients' data with advanced-stage rare cancer in Asia-Pacific region. Data includes clinical information, details of treatment, prognosis, pathological diagnosis and genetic biomarkers by next-generation sequencing.

The relationship between cancer types and prognosis, the effect of treatments, and the cancer type-specific incidence of genomic alterations will be investigated to discover more specific and effective treatment.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-10-24
• Study Start: 2021-11-30
• Study First Submitted QC: 2022-01-19
• Study First Posted: 2022-02-01
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-20
• Last Update Posted: 2024-03-22
• Primary Completion: 2027-03-31
• Study Completion: 2030-03-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

1. Patients with a histological diagnosis of rare cancer, cancer of unknown primary origin, or cancer of rare tissue subtypes of common cancers. (Defined in protocol.)
2. Patients with Advanced stage cancer.

Exclusion Criteria

1. Patients with complications of cognitive impairment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall incidence of any genomic alteration in overall population	1 year	Overall incidence of any genomic alteration in overall population
Overall incidence of any genomic alteration in patients with a certain cancer type	1 year	Overall incidence of any genomic alteration in patients with a certain cancer type

Secondary Outcome Measures

Name	Time	Method
Incidence of individual genomic alteration in overall population	1 year	The incidence of individual genomic alterations in overall population
Incidence of individual genomic alteration in patients with a certain cancer type	1 year	The incidence of individual genomic alterations in patients with a certain cancer type

Trial Locations

Locations (18)

National Cancer Center Hospital, Japan; 🇯🇵 Chuo-ku, Tokyo, Japan

National Cancer Center Korea; 🇰🇷 Seoul, Korea, Republic of

Hospital Sultan Ismail; 🇲🇾 Johor Bahru, Johor, Malaysia

Hospital Pulau Pinang; 🇲🇾 Pulau Pinang, Penang, Malaysia

Sarawak General Hospital; 🇲🇾 Kuching, Sarawak, Malaysia

Hospital Kuala Lumpur; 🇲🇾 Kuala Lumpur, Malaysia

University Malaya Medical Center; 🇲🇾 Kuala Lumpur, Malaysia

Institut Kanser negara; 🇲🇾 Putrajaya, Malaysia

St. Luke's Medical Center; 🇵🇭 Manila, Philippines

National Taiwan University Hospital; 🇨🇳 Taipei, Zhongzheng, Taiwan

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