The Effects of Different Dexmedetomidine on the Propofol Requirement for Loss of Consciousness Undergoing Bispectral Index
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 73
- 主要终点
- The propofol requirement for pretreatment of dexmedetomidine by micro-pump until loss of consciousness
研究概览
简要总结
The purpose of this study is to evaluate the effects of different dexmedetomidine on the propofol requirement for loss of consciousness undergoing bispectral index.
详细描述
It has been shown that dexmedetomidine was an efficacious and safe adjuvant in general anaesthesia. Administration of dexmedetomidine during the preoperative period has been demonstrated to reduce the requirement of opioid analgesics and other sedative and hypnotic drugs.Therefore, the study is designed to measure the effect of intravenous dexmedetomidine premedication on the propofol dose requirement and bispectral index at loss of consciousness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA physical status I-II
- •Aged 18-65 years
- •Body Mass Index 18.0～24.5 kg/m2
- •Without hearing impairment
排除标准
- •Bradycardia
- •Atrioventricular block
- •Neurologic disorder and recent use of psychoactive medication
- •Allergic to the drugs
研究组 & 干预措施
Group dexmedetomidine 1.0 µg/kg
25 eligible patients are received dexmedetomidine 1.0 µg/kg intravenously for 10 minutes
干预措施: dexmedetomidine 1.0 µg/kg (Drug)
Group control
24 eligible patients are received equal volumes of saline intravenously for 10 minutes
干预措施: normal saline (Other)
Group dexmedetomidine 0.5 µg/kg
24 eligible patients are received dexmedetomidine 0.5 µg/kg intravenously for 10 minutes
干预措施: dexmedetomidine 0.5 µg/kg (Drug)
结局指标
主要结局
The propofol requirement for pretreatment of dexmedetomidine by micro-pump until loss of consciousness
时间窗: To infuse dexmedetomidine and saline completely ten minutes after
次要结局
- The bispectral index values when patients loss of consciousness(To infuse dexmedetomidine and saline completely ten minutes after)