The Effects of Different Dexmedetomidine on the Propofol Requirement for Loss of Consciousness Undergoing Bispectral Index
Overview
- Phase
- Not Applicable
- Intervention
- dexmedetomidine 1.0 µg/kg
- Conditions
- Loss of Consciousness
- Sponsor
- General Hospital of Ningxia Medical University
- Enrollment
- 73
- Primary Endpoint
- The propofol requirement for pretreatment of dexmedetomidine by micro-pump until loss of consciousness
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to evaluate the effects of different dexmedetomidine on the propofol requirement for loss of consciousness undergoing bispectral index.
Detailed Description
It has been shown that dexmedetomidine was an efficacious and safe adjuvant in general anaesthesia. Administration of dexmedetomidine during the preoperative period has been demonstrated to reduce the requirement of opioid analgesics and other sedative and hypnotic drugs.Therefore, the study is designed to measure the effect of intravenous dexmedetomidine premedication on the propofol dose requirement and bispectral index at loss of consciousness.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ASA physical status I-II
- •Aged 18-65 years
- •Body Mass Index 18.0～24.5 kg/m2
- •Without hearing impairment
Exclusion Criteria
- •Bradycardia
- •Atrioventricular block
- •Neurologic disorder and recent use of psychoactive medication
- •Allergic to the drugs
Arms & Interventions
Group dexmedetomidine 1.0 µg/kg
25 eligible patients are received dexmedetomidine 1.0 µg/kg intravenously for 10 minutes
Intervention: dexmedetomidine 1.0 µg/kg
Group control
24 eligible patients are received equal volumes of saline intravenously for 10 minutes
Intervention: normal saline
Group dexmedetomidine 0.5 µg/kg
24 eligible patients are received dexmedetomidine 0.5 µg/kg intravenously for 10 minutes
Intervention: dexmedetomidine 0.5 µg/kg
Outcomes
Primary Outcomes
The propofol requirement for pretreatment of dexmedetomidine by micro-pump until loss of consciousness
Time Frame: To infuse dexmedetomidine and saline completely ten minutes after
Secondary Outcomes
- The bispectral index values when patients loss of consciousness(To infuse dexmedetomidine and saline completely ten minutes after)