A randomized double-blind controlled trial comparing 0.2 mg, 0.1 mg, or without intrathecal morphine combined with periarticular injection in unilateral total knee arthropla

Phase 4

Recruiting

• Conditions: Post operative pain control in total knee arthroplasty Side effect profiles of intrathecal morphine Efficacy of intrathecal morphine Efficacy of local infiltration analgesia; side effect morphine; intrathecal morphine; spinal morphine; local infiltration analgesia; total knee arthroplasty; PONV

• Registration Number: TCTR20180825003
• Lead Sponsor: avamindradhiraj University research found

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-08-25
• Study Completion: 2019-04-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Age 45-85 years old
- ASA physical status I-III
- Scheduled for elective primary unilateral TKA

Exclusion Criteria

- Contraindication to neuraxial anesthesia
- Allergy to any of the ingredients of the periarticular injection solution
- Allergy to acetaminophen or any medications use in research study
- Revision and/or bilateral TKA
- Chronic pain unrelated to their knee joint
- Chronic opioid use (3 months or longer)
- Preexisting neuropathy involving operative site
- Inflammatory joint disease
- Major psychological problems
- History of coronary artery bypass graft surgery
- History of gastrointestinal ulcer or bleeding
- Pregnancy or breastfeeding
- Impaired renal function(Glomerular Filtration Rate (GFR) < 30 mL/min)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
side-effect profiles of 0.1 mg and 0.2 mg intrathecal morphine combine with periarticular injection post operative at 0,4,8,12,16,24,48,72 hr nausea/vomiting score,pruritic score, Ramsey sedation score

Secondary Outcome Measures

Name	Time	Method
The incidence of side-effect profile of intrathecal morphine in the first 24 h post operative at 0,4,8,12,16,24,48,72 hr nausea/vomiting score,pruritic score, Ramsey sedation score,The efficacy of intrathecal morphine in the first 24 hours. post operative at 0,4,8,12,16,24 hr pain score