Can periarticular knee injection of multimodal agents Levobupivicaine, Morphine, Ketorolac and adrenaline improve postoperative pain and function following primary total knee arthroplasty? - Periarticular infiltration following total knee arthroplasty

• Conditions: Osteoarthritis- those patients requiring total knee arthroplasty

• Registration Number: EUCTR2010-020466-18-GB
• Lead Sponsor: niversity of Warwick

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-08-18
• Last Update Posted: 19 March 2012

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

All patients undergoing an elective primary unilateral total knee arthroplasty under the care of an orthopaedic consultant at University Hospitals Coventry and Warwickshire NHS trust will be eligible for the trial unless they fit the exclusion criteria.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

The following patients will not be eligible for entry to the trial:
Those with sufficient cognitive impairment that they would be unable complete questionnaire (cognitive impairment).
Those patients who lack capacity under the Mental Capacity Act 2005
Those patients with a pre-operative history of neurological abnormality in the ipsilateral leg e.g. history of stroke, neurogenic pain or previous nerve injury.
Those patients having spinal anaesthesia.
Those patients with a specific contraindication to the analgesic agents used:
Morphine:
?Hypersensitivity reaction

Ketorolac:
?Active or previous peptic ulcer. History of upper gastrointestinal bleeding or perforation, related to previous NSAID therapy.
?Haemorrhagic diatheses, including coagulation disorders
?Hypersensitivity to ketorolac trometamol or other NSAIDs
?Moderate or severe renal impairment (serum creatinine > 160 micromol/l)

Levobupivicaine:
?Levobupivacaine solutions are contra-indicated in patients with a known hypersensitivity to levobupivacaine, local anaesthetics of the amide type or any of the excipients
?Uncontrolled angina
?2nd/ 3rd degree heart block

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified