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临床试验/NCT00809432
NCT00809432已完成不适用

Beneficial Cardiovascular Effects of Reducing Exposure to Particulate Air Pollution With a Simple Facemask

University of Edinburgh1 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2008年8月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
15
试验地点
1
主要终点
Ambulatory blood pressure

研究概览

简要总结

Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia. The study objectives were to assess the potential cardiovascular benefits of reducing personal particulate air pollution exposure by wearing a facemask in healthy volunteers.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
None

入排标准

性别
All
接受健康志愿者

入选标准

  • Healthy volunteers

排除标准

  • Current smokers
  • Significant occupational exposure to air pollution
  • Regular medication use (except oral contraceptive pill)
  • Intercurrent illness

结局指标

主要结局

Ambulatory blood pressure

时间窗: During 24 hour study period

次要结局

  • Heart rate(During 24 hour study period)
  • Heart rate variability(During 24 hour study period)
  • Personal air pollution exposure(During 2 hour city centre walk)

研究者

申办方类型
Other

研究点 (1)

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