A Comparative Study of changes in knee MRI findings after single and double Centrifuged platelet rich plasma and placebo (normal saline injection) in Patients with Knee Osteoarthritis: A Controlled Randomized Trial with a six-Month Follow –up

Iran University of Medical Sciences0 个研究点目标入组 45 人开始时间: 待定最近更新: 2021年11月29日

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•Patients with grade 2 or 3 primary osteoarthritis of the knee as determined by the Kellgren and Lawrence criteria (knee pain, morning stiffness less than 30 minutes, crepitus on movement and radiological signs of osteoarthritis include joint space loss, subchondral bone sclerosis and the formation of osteophytes in knee)
•Patients aged 50-75 years
•Patients who have persistent knee pain for at least six months and with an intensity of at least 4 according to the VAS scale in activities such as going up and down stairs, sitting for long periods and squatting
•Patients who are able to walk independently for at least 30 meters
•Patients with a body mass index equal to or less than 35
•The patient has full consent to participate in the study
•The patient has a balanced mental state

•The patient has any contraindications for MRI, including aneurysm clips, pacemakers, metal devices in the body, and claustrophobia
•The patient has a history of intra-articular injection in the knee during the last six months
•The patient has neuromuscular diseases
•The patient has a history of acute traumatic injury to other ligaments and structures of the knee joint with the approval of a specialist
•The patient has a history of surgery or previous injury in the knee and other lower limb joints over the last year
•The patient has bone implants
•The patient has a new fracture in the lower extremities during the last year
•The patient has malignant tumors
•The patient has participated in exercise therapy and physiotherapy programs during the last three months

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